Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638338 | 0.88 | S1PR1 (0.43) | MAPTLMNAKMT2AMEN1S1PR1 | |
| SCHEMBL6685612 | 0.87 | S1PR1 (0.46) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL6641308 | 0.87 | PKM (0.51) | MAPTPKMLMNAKMT2AMEN1 | |
| SCHEMBL6803739 | 0.84 | SMO (0.48) | MAPTPKMLMNAKMT2AMEN1 | |
| SCHEMBL7081482 | 0.83 | PKM (0.49) | MAPTPKMLMNAKMT2AMEN1 | |
| SCHEMBL6798429 | 0.83 | SMO (0.57) | MAPTPKMLMNATRPV1SMO | |
| SCHEMBL6683684 | 0.83 | HTR2A (0.47) | S1PR1S1PR3HTR2AHTR2CHTR2B | |
| SCHEMBL6643055 | 0.82 | SMO (0.46) | MAPTPKMLMNAKMT2AMEN1 | |
| SCHEMBL6791040 | 0.79 | PKM (0.49) | MAPTPKMLMNAKMT2AMEN1 | |
| SCHEMBL6640573 | 0.79 | LMNA (0.52) | MAPTLMNAKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |