Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30630362 | 1.00 | LMNA (0.40) | LMNAHTTTDP1KDM4ESLC2A1 | |
| SCHEMBL2616406 | 0.82 | LMNA (0.48) | LMNAHTTTDP1KDM4ESLC2A1 | |
| SCHEMBL6640669 | 0.80 | LMNA (0.35) | LMNAHTTTDP1KDM4ESLC2A1 | |
| SCHEMBL3476708 | 0.77 | LMNA (0.46) | LMNAHTTTDP1KDM4ESLC2A1 | |
| SCHEMBL113414 | 0.73 | LMNA (0.43) | LMNAHTTTDP1KDM4ESLC2A1 | |
| SCHEMBL29427272 | 0.73 | LMNA (0.43) | LMNAHTTTDP1KDM4ESLC2A1 | |
| SCHEMBL29962993 | 0.71 | HDAC8 (0.30) | HDAC8 | |
| SCHEMBL8651749 | 0.69 | KDM4E (0.33) | LMNAHTTTDP1KDM4ERAB9A | |
| SCHEMBL11737371 | 0.69 | TSHR (0.36) | LMNAHTTTSHR | |
| Formic Acid SCHEMBL30297733 | 0.68 | LMNA (0.35) | LMNAHTTTDP1KDM4ESLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022166796-A1 | PYRIMIDINE OR PYRIDINE AND HETEROCYCLIC ADENOSINE RECEPTOR INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2022-08-11 | — | — | WO | disclosed |
| EP-1397359-A1 | 1-BIARYL-1,8-NAPTHYRIDIN-4-ONE PHOSPHODIESTERASE-4 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094823-A1 | 1-BIARYL-1,8-NAPTHYRIDIN-4-ONE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-11-28 | — | — | WO | disclosed |