Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30630362 | 0.80 | LMNA (0.40) | LMNAHTTKDM4ETDP1SLC2A1 | |
| SCHEMBL6640541 | 0.80 | LMNA (0.40) | LMNAHTTKDM4ETDP1SLC2A1 | |
| SCHEMBL2616406 | 0.76 | LMNA (0.48) | LMNAHTTKDM4ETDP1SLC2A1 | |
| SCHEMBL5943305 | 0.71 | MLYCD (0.33) | — | |
| SCHEMBL3476708 | 0.71 | LMNA (0.46) | LMNAHTTKDM4ETDP1SLC2A1 | |
| SCHEMBL113414 | 0.67 | LMNA (0.43) | LMNAHTTKDM4ETDP1SLC2A1 | |
| SCHEMBL29427272 | 0.67 | LMNA (0.43) | LMNAHTTKDM4ETDP1SLC2A1 | |
| SCHEMBL8651749 | 0.67 | KDM4E (0.33) | LMNAHTTKDM4ETDP1 | |
| SCHEMBL7192 | 0.65 | CYP2C19 (0.47) | LMNAKDM4EKMT2AALDH1A1 | |
| SCHEMBL6472876 | 0.65 | CYP2C19 (0.47) | LMNAKDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397359-A1 | 1-BIARYL-1,8-NAPTHYRIDIN-4-ONE PHOSPHODIESTERASE-4 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094823-A1 | 1-BIARYL-1,8-NAPTHYRIDIN-4-ONE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-11-28 | — | — | WO | disclosed |