Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 8/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643853 | 0.87 | BCHE (0.42) | NPC1ALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL6640766 | 0.84 | POLB (0.49) | NPC1ALDH1A1MAPTRAB9ALMNA | |
| Formaldehyde SCHEMBL27548620 | 0.82 | POLB (0.47) | NPC1ALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL6638954 | 0.81 | NPC1 (0.48) | NPC1ALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL6648077 | 0.80 | NPC1 (0.47) | NPC1ALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL1429779 | 0.80 | BCHE (0.63) | BCHEPOLBACHEL3MBTL1 | |
| SCHEMBL9732204 | 0.80 | ALDH1A1 (0.52) | ALDH1A1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL6646033 | 0.76 | ALDH1A1 (0.70) | NPC1ALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL6643965 | 0.76 | BCHE (0.65) | BCHEACHE | |
| SCHEMBL6643165 | 0.75 | BCHE (0.67) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109813-B1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RES LTD (GB) | 2004-08-11 | — | — | EP | disclosed |
| US-6433175-B1 | ANTISEROTONINE AGENTS | VERNALIS RESEARCH LIMITED (GB) | 2002-08-13 | — | — | US | disclosed |
| EP-1109813-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012510-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |