Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 6/20 | 0.43 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640766 | 0.97 | POLB (0.49) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6640712 | 0.85 | ABCC2 (0.41) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6640689 | 0.83 | POLB (0.46) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6638954 | 0.83 | NPC1 (0.48) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6648077 | 0.82 | NPC1 (0.47) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL1429779 | 0.82 | BCHE (0.63) | POLBBCHEL3MBTL1ACHE | |
| SCHEMBL6640702 | 0.82 | NPC1 (0.44) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL13132155 | 0.81 | NPC1 (0.54) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL29165493 | 0.79 | MAPT (0.47) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL6646033 | 0.79 | ALDH1A1 (0.70) | POLBNPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1165537-C | Pyrroloindoles, pyridoindoles and aza * -indoles as 5-HT 2C agonists | О | 2004-09-08 | — | — | CN | disclosed |
| CN-1325399-A | Pyrroloindoles, pyridoindoles and azaindoles as 5-HT 2C agonists | CEREBRUS RES LTD (GB) | 2001-12-05 | — | — | CN | disclosed |