Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.73 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.73 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.63 |
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
| ▸ | HTR2C | P28335 | 3/20 | 0.62 |
| ▸ | HTR1D | P28221 | 3/20 | 0.62 |
| ▸ | HTR1B | P28222 | 2/20 | 0.62 |
| ▸ | HTR1E | P28566 | 2/20 | 0.62 |
| ▸ | HTR7 | P34969 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | HTR2B | P41595 | 2/20 | 0.62 |
| ▸ | HTR5A | P47898 | 2/20 | 0.62 |
| ▸ | HTR6 | P50406 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430044 | 0.91 | HTR2A (0.80) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL23649345 | 0.90 | HTR2A (0.69) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL4492982 | 0.85 | GPR84 (0.76) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL28116971 | 0.84 | HTR2A (0.71) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL29444443 | 0.84 | HTR2A (0.71) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL733712 | 0.84 | HTR2A (0.71) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL29791683 | 0.84 | HTR2A (1.00) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL13715518 | 0.84 | HTR2A (0.71) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL1520598 | 0.84 | HTR2A (1.00) | HTR2ATRPM8GPR84SLC6A4HTR1A | |
| SCHEMBL27929625 | 0.83 | GPR84 (1.00) | HTR2ATRPM8GPR84SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100455570-C | Quinolinone/benzo oxazinone derivatives and uses thereof | HOFFMANN LA ROCHE (CH) | 2009-01-28 | — | — | CN | disclosed |
| CN-1759101-A | Quinolinone / benzoxazinone derivatives and uses thereof | HOFFMANN LA ROCHE (CH) | 2006-04-12 | — | — | CN | disclosed |
| EP-1078928-B1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-05-12 | — | — | EP | disclosed |
| US-6486171-B2 | USEFUL IN THE TREATMENT OF SOME CENTRAL NERVOUS SYSTEM DISORDERS INCLUDING AS AN ANTIDEPRESSANT; 4-(1-(2-NAPHTHYL)ETHYL)-4- PIPERIDINYL)THIENO(3,2-C)PYRIDINE, FOR EXAMPLE | LES LABORATOIRES SERVIER (FR) | 2002-11-26 | — | — | US | disclosed |
| US-20020161228-A1 | Piperidine compounds | ADIR ET COMPAGNIE | 2002-10-31 | — | — | US | disclosed |
| US-6399616-B1 | 4-(4-(2-(5-(1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL)ETHYL)-1 -PIPERAZINYL)FURO(3,2-C)PYRIDINE; COMBINED SEROTONIN REUPTAKE INHIBITOR AND PARTIAL AGONIST OF 5-HT RECEPTORS; REDUCED LATENCY; DEPRESSION | LES LABORATOIRES SERVIER (FR) | 2002-06-04 | — | — | US | disclosed |
| EP-1078928-A1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-02-28 | — | — | EP | disclosed |
| EP-0187619-A2 | 1,3-Disubstituted tetrahydropyridines | CIBA-GEIGY AG (CH) | 1986-07-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161228-A1 | Piperidine compounds | OTC, NPPA, AQP4 | HTR2A 748/4885TRPM8 2116/4885GPR84 2760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.