Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634986 | 0.84 | TAAR1 (0.40) | FLT3KAT2BKDM4EHSD17B10MEN1 | |
| SCHEMBL7447378 | 0.82 | TRPA1 (0.36) | IDO1MEN1KMT2A | |
| SCHEMBL6639584 | 0.78 | NPC1 (0.40) | FLT3KDM4EKMT2A | |
| SCHEMBL4600275 | 0.78 | TRPA1 (0.33) | — | |
| SCHEMBL10798671 | 0.73 | CHEK1 (0.54) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL6637171 | 0.73 | KDM4E (0.30) | KDM4EHSD17B10 | |
| SCHEMBL3123233 | 0.72 | CHEK1 (0.45) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL4899544 | 0.71 | CHEK1 (0.41) | CHEK1PIM1IDO1LTKLIMK1 | |
| SCHEMBL4598872 | 0.70 | RAB9A (0.35) | KDM4ELMNAHTTMEN1KMT2A | |
| SCHEMBL2182874 | 0.69 | CHEK1 (0.41) | CHEK1PIM1IDO1LTKLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165557-B1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORP (US) | 2004-09-29 | — | — | EP | disclosed |