Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAD52 | P43351 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641965 | 0.90 | MAPT (0.42) | MAPTRAD52ALDH1A1KDM4EPOLB | |
| SCHEMBL6644195 | 0.86 | MAPT (0.44) | MAPTRAD52ALDH1A1POLBGAA | |
| SCHEMBL6644261 | 0.84 | MEN1 (0.39) | MAPTRAD52ALDH1A1KDM4EPOLB | |
| SCHEMBL6643025 | 0.80 | KMT2A (0.39) | MAPTRAD52ALDH1A1KDM4EPOLB | |
| SCHEMBL8367618 | 0.76 | BDKRB2 (0.43) | MAPTRAD52POLBGAA | |
| SCHEMBL6640229 | 0.75 | POLB (0.42) | MAPTRAD52ALDH1A1POLBGAA | |
| SCHEMBL6645090 | 0.74 | POLB (0.43) | MAPTRAD52ALDH1A1POLBGAA | |
| SCHEMBL6643020 | 0.73 | KMT2A (0.39) | MAPTRAD52ALDH1A1KDM4EPOLB | |
| SCHEMBL6644197 | 0.70 | GAA (0.40) | MAPTRAD52ALDH1A1POLBGAA | |
| SCHEMBL9158223 | 0.70 | ALDH1A1 (0.55) | MAPTALDH1A1KDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807105-B1 | PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-06-16 | — | — | EP | disclosed |
| US-5994368-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-30 | — | — | US | disclosed |
| WO-1996013485-A1 | PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-09 | — | — | WO | disclosed |