Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402351 | 0.74 | GRM5 (0.41) | NPC1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL10847407 | 0.74 | KDM4E (0.49) | NPC1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL10835241 | 0.73 | RAB9A (0.56) | TRIM24TRIM33NPC1KMT2ARAB9A | |
| SCHEMBL1376360 | 0.71 | POLB (0.42) | TRIM24TRIM33NPC1KMT2ARAB9A | |
| SCHEMBL31023942 | 0.71 | TRIM24 (0.52) | TRIM24TRIM33NPC1KMT2ARAB9A | |
| SCHEMBL1376029 | 0.71 | TRIM24 (0.52) | TRIM24TRIM33NPC1KMT2ARAB9A | |
| SCHEMBL1376342 | 0.70 | DHODH (0.56) | TRIM24TRIM33NPC1KMT2ARAB9A | |
| SCHEMBL9402355 | 0.70 | GRM4 (0.52) | NPC1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL16627413 | 0.69 | RAB9A (0.62) | TRIM24TRIM33NPC1KMT2ARAB9A | |
| SCHEMBL16627420 | 0.69 | ALDH1A1 (0.44) | TRIM24TRIM33NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1236725-B1 | NOVEL 1,8-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | GRELAN PHARMACEUTICAL CO (JP) | 2004-03-10 | — | — | EP | disclosed |
| US-6642250-B2 | As phosphodiesterase inhibitor for prophylaxis and therapy of bronchial asthma; pneumonic diseases, pulmonary emphysema, chronic obstructive pulmonary disease acute respiratory distress syndrome (ARDS), and other respiratory diseases | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2003-11-04 | — | — | US | disclosed |
| US-20030036651-A1 | Novel 1,8-naphthyridin-2(1h)-one derivatives | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2003-02-20 | — | — | US | disclosed |
| EP-1236725-A1 | NOVEL 1,8-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | Grelan Pharmaceutical Co., Ltd. (JP) | 2002-09-04 | — | — | EP | disclosed |
| US-5364860-A | Naphthyridine compounds which inhibit tyrosine kinase and their pharmaceutical compositions | LABORATOIRES UPSA (FR) | 1994-11-15 | — | — | US | disclosed |
| US-4786642-A | ANTIULCER | SOCIETE ANONYME: CARPIBEM (FR) | 1988-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036651-A1 | Novel 1,8-naphthyridin-2(1h)-one derivatives | PDE3B, PDE4A, PDE4B | TRIM24 3020/4885TRIM33 3292/4885NPC1 2324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.