SCHEMBL664283

SCHEMBL664283

NC(=O)CCc1c[nH]c2ccccc12

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.70
ALDH1A1 P00352 2/20 0.70
GAA P10253 1/20 0.70
MPO P05164 3/20 0.64
CYP1A2 P05177 2/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2D6 P10635 1/20 0.62
CYP2A6 P11509 1/20 0.62
NFKB1 P19838 1/20 0.62
HTR1D P28221 1/20 0.62
HTR1B P28222 1/20 0.62
HTR2A P28223 1/20 0.62
HTR2C P28335 1/20 0.62
HTR7 P34969 1/20 0.62
CTSK P43235 1/20 0.62
HTR6 P50406 1/20 0.62
CYP2A13 Q16696 1/20 0.62
TAAR1 Q96RJ0 1/20 0.62
PMP22 Q01453 1/20 0.60
KMT2A Q03164 4/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29053759 0.98 MAPT (0.68) MAPTALDH1A1GAAMPOCYP1A2
SCHEMBL4092371 0.92 ALDH1A1 (0.75) MAPTALDH1A1GAAMPOCYP1A2
SCHEMBL2378991 0.90 ALDH1A1 (0.69) MAPTALDH1A1GAAMPOCYP1A2
SCHEMBL2379635 0.89 ALDH1A1 (0.67) MAPTALDH1A1GAAMPOCYP1A2
Indolylpropionic Acid SCHEMBL4973575 0.85 ALDH1A1 (0.71) MAPTALDH1A1GAAMPOCYP1A2
Indolylpropionic Acid SCHEMBL29521227 0.85 MAPT (0.68) MAPTALDH1A1GAAMPOCYP1A2
Indolylpropionic Acid SCHEMBL29374161 0.85 MAPT (0.68) MAPTALDH1A1GAAMPOCYP1A2
SCHEMBL28378507 0.85 MAPT (0.68) MAPTALDH1A1GAAMPOCYP1A2
Indolylpropionic Acid SCHEMBL195405 0.85 MAPT (0.68) MAPTALDH1A1GAAMPOCYP1A2
Tryptamine SCHEMBL16990205 0.84 HTR2C (0.78) MAPTALDH1A1GAAMPOCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 274 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-119095964-A Multi-tail and multi-cap mRNA and uses thereof 博德研究所 2024-12-06 CN claimed
CN-118076741-A Modified mRNA, modified non-coding RNA and uses thereof 布罗德研究所股份有限公司 2024-05-24 CN claimed
CN-116440126-A Application of 1H-indole-3-propionamide sodium channel regulator 浙江大学 2023-07-18 CN claimed
CN-116286830-A Aptamer 中国人民解放军军事科学院军事医学研究院 2023-06-23 CN claimed
CN-115151263-A Aptamers and uses thereof 爱普济德生物技术有限公司 2022-10-04 CN claimed
US-20120094977-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION DENDREON CORPORATION (US) 2012-04-19 US claimed
EP-1957454-B1 METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES HOFFMANN LA ROCHE (CH) 2011-07-20 EP claimed
JP-2002537300-A 2002-11-05 JP claimed
WO-2002048099-A1 CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMOURS MERCK PATENT GMBH (DE) 2002-06-20 WO claimed
US-20020016329-A1 2-Amino-6-anilino-purines and their use as medicaments NOVARTIS AG (CH) 2002-02-07 US claimed
EP-1153024-A1 2-AMINO-6-ANILINO-PURINES AND THEIR USE AS MEDICAMENTS Novartis AG (CH) 2001-11-14 EP claimed
WO-2000049018-A1 2-AMINO-6-ANILINO-PURINES AND THEIR USE AS MEDICAMENTS NOVARTIS AG (CH) 2000-08-24 WO claimed
EP-0874846-A1 PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION Novartis AG (CH) 1998-11-04 EP claimed
WO-1997016452-A1 PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 1997-05-09 WO claimed
EP-0669830-A4 SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE. MERCK & CO INC (US) 1997-02-26 EP claimed
EP-0682663-A1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 1995-11-22 EP claimed
EP-0669830-A1 SUBSTITUTED DIPEPTIDE ANALOGS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO. INC. (US) 1995-09-06 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020016329-A1 2-Amino-6-anilino-purines and their use as medicaments CDK14, CDK1, CCNB1 MAPT 2815/4885ALDH1A1 4801/4885GAA 4129/4885
US-20120094977-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION TRPC4, TRPC3, TRPC1 MAPT 3379/4885ALDH1A1 4742/4885GAA 4570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.