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Phthalimide

Phthalimide

SCHEMBL6643530

CC(=O)N(C)c1ccc(Cl)c(COc2cccc3c(N4CCOCC4)cc(C)nc23)c1Cl.O=C1NC(=O)c2ccccc21

nearest known ligand 0.62

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Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BDKRB2 P30411 20/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phthalimide SCHEMBL6638345 0.93 BDKRB2 (0.59) BDKRB2
SCHEMBL6643523 0.86 BDKRB2 (0.63) BDKRB2
SCHEMBL6640651 0.85 BDKRB2 (0.68) BDKRB2
Phthalimide SCHEMBL6974162 0.85 BDKRB2 (0.61) BDKRB2
SCHEMBL6638337 0.79 BDKRB2 (0.62) BDKRB2
SCHEMBL6643549 0.78 BDKRB2 (0.67) BDKRB2
SCHEMBL6644131 0.77 BDKRB2 (1.00) BDKRB2
SCHEMBL6644135 0.77 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL6958840 0.76 BDKRB2 (0.69) BDKRB2
SCHEMBL8014671 0.76 BDKRB2 (0.89) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0807105-B1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 2004-06-16 — — EP disclosed
EP-0807105-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-19 — — EP disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 — — WO disclosed