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Sugi Predict / Compounds / Phthalimide

Phthalimide

Phthalimide

SCHEMBL6974162

CC(=O)N(C)c1ccc(Cl)c(COc2cccc3c(-n4ccnc4)cc(C)nc23)c1Cl.O=C1NC(=O)c2ccccc21

nearest known ligand 0.61

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Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BDKRB2 P30411 17/20 0.61
▸ RORC P51449 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6958840 0.92 BDKRB2 (0.69) BDKRB2RORC
SCHEMBL6974156 0.86 BDKRB2 (0.65) BDKRB2RORC
Phthalimide SCHEMBL6638345 0.86 BDKRB2 (0.59) BDKRB2
SCHEMBL6975739 0.85 BDKRB2 (0.70) BDKRB2RORC
Phthalimide SCHEMBL6643530 0.85 BDKRB2 (0.62) BDKRB2
SCHEMBL6974081 0.84 BDKRB2 (0.78) BDKRB2RORC
SCHEMBL1564696 0.82 BDKRB2 (0.70) BDKRB2RORC
SCHEMBL6974368 0.82 BDKRB2 (0.79) BDKRB2
SCHEMBL6958849 0.81 BDKRB2 (0.71) BDKRB2RORC
SCHEMBL6967220 0.81 BDKRB2 (0.75) BDKRB2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0900203-B1 QUINOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS FUJISAWA PHARMACEUTICAL CO (JP) 2003-03-19 — — EP disclosed
US-6083959-A BRADYKININ ANTAGONISTS; FOR THE PREVENTION AND/OR THE TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES SUCH AS ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-04 — — US disclosed