Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6644191 | 0.87 | KDM4E (0.41) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL4767736 | 0.86 | OPRM1 (0.52) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL19284729 | 0.83 | GPR119 (0.47) | KDM4EMAPTTHRBSMN1; SMN2GPR119 | |
| SCHEMBL30233524 | 0.82 | GPR119 (0.53) | KDM4EMAPTTHRBSMN1; SMN2GPR119 | |
| SCHEMBL1513166 | 0.82 | GPR119 (0.53) | KDM4EMAPTTHRBSMN1; SMN2GPR119 | |
| SCHEMBL7629914 | 0.82 | OPRM1 (0.48) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL31270465 | 0.81 | JAK2 (0.42) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL29212348 | 0.81 | JAK2 (0.42) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL557776 | 0.81 | KDM4E (0.70) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL15000897 | 0.80 | GPR119 (0.50) | KDM4EALDH1A1MAPTTHRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-A2 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003076398-A2 | PYRROLE-2, 5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-09-18 | — | — | WO | disclosed |