⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1043398 | 0.86 | — | — | |
| SCHEMBL10354272 | 0.86 | CNR1 (0.46) | — | |
| SCHEMBL15774854 | 0.79 | CNR1 (0.42) | — | |
| SCHEMBL6387092 | 0.79 | — | — | |
| SCHEMBL6068913 | 0.77 | — | — | |
| SCHEMBL6467649 | 0.76 | FAAH (0.58) | — | |
| SCHEMBL6069030 | 0.75 | CNR1 (0.53) | — | |
| SCHEMBL6030467 | 0.75 | CNR1 (0.59) | — | |
| SCHEMBL435772 | 0.72 | — | — | |
| SCHEMBL6391712 | 0.72 | LMNA (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |
| EP-1395554-A1 | SUBSTITUTED CARBAZOLES AS INHIBITORS OF SPLA2 | ELI LILLY AND COMPANY (US) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002079154-A1 | SUBSTITUTED CARBAZOLES AS INHIBITORS OF SPLA2 | ELI LILLY AND COMPANY (US) | 2002-10-10 | — | — | WO | disclosed |