Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643002 | 0.91 | MAPK1 (0.38) | LMNAKMT2AGAANOS3NOS1 | |
| SCHEMBL6643026 | 0.88 | NOS3 (0.51) | LMNAKMT2AGAANOS3NOS1 | |
| SCHEMBL6641968 | 0.81 | NOS3 (0.51) | KMT2AGAANOS3NOS1NOS2 | |
| SCHEMBL6640660 | 0.77 | MAPK1 (0.37) | LMNAKMT2AGAANOS3NOS1 | |
| SCHEMBL6646342 | 0.74 | NOS3 (0.50) | LMNAKMT2AGAANOS3NOS1 | |
| SCHEMBL6642433 | 0.72 | NOS3 (0.44) | GAANOS3NOS1NOS2TSHR | |
| SCHEMBL6643494 | 0.69 | ALDH1A1 (0.37) | KMT2ANOS3NOS1NOS2ALDH1A1 | |
| SCHEMBL6643304 | 0.67 | NOS3 (0.50) | LMNAKMT2AGAANOS3NOS1 | |
| SCHEMBL6645276 | 0.67 | NOS3 (0.44) | KMT2ANOS3NOS1NOS2MEN1 | |
| SCHEMBL6645803 | 0.67 | NOS3 (0.44) | KMT2ANOS3NOS1NOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054869-B1 | 3,4-DIHYDROQUINOLINE DERIVATIVES AS NITROGEN MONOXIDE SYNTHASE (NOS) INHIBITORS | SCHERING AG (DE) | 2004-09-22 | — | — | EP | disclosed |
| US-6391887-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASE; CARDIOVASCULAR DISORDERS | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-05-21 | — | — | US | disclosed |