Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 9/20 | 0.38 |
| ▸ | NCF1 | P14598 | 5/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NCK1 | P16333 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638905 | 0.76 | PLAU (0.40) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL30359506 | 0.76 | RPS6KA5 (0.36) | MAPTKDM4EALDH1A1 | |
| SCHEMBL1165613 | 0.76 | RPS6KA5 (0.36) | MAPTKDM4EALDH1A1 | |
| SCHEMBL31663159 | 0.76 | PLAU (0.40) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL4045372 | 0.74 | PLAU (0.43) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL24514808 | 0.71 | HDAC8 (0.32) | MAPTKDM4EALDH1A1 | |
| SCHEMBL2619134 | 0.71 | CYP1A2 (0.40) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL28489635 | 0.71 | CYP1A2 (0.33) | MAPTHTTKDM4EALDH1A1 | |
| SCHEMBL20305881 | 0.71 | ALDH1A1 (0.33) | MAPTKDM4EALDH1A1CASP1MEN1 | |
| SCHEMBL2928822 | 0.71 | BCHE (0.46) | BACE1NCF1NOS2HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-A4 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-02-11 | — | — | EP | claimed |
| EP-1066286-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-10 | — | — | EP | claimed |
| WO-1999045009-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-10 | — | — | WO | claimed |