Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 10/20 | 0.41 |
| ▸ | NCF1 | P14598 | 10/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | NCK1 | P16333 | 1/20 | 0.41 |
| ▸ | CYBB | P04839 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31663159 | 0.84 | PLAU (0.40) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL3638905 | 0.84 | PLAU (0.40) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL25106981 | 0.81 | BACE1 (0.41) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL25449341 | 0.77 | BACE1 (0.38) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL6644292 | 0.74 | PLAU (0.40) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL8628087 | 0.74 | PLAU (0.59) | PLAUBACE1NCF1NOS2NCK1 | |
| SCHEMBL2933558 | 0.74 | PRMT5 (0.46) | BACE1NCF1NOS2 | |
| SCHEMBL30531684 | 0.74 | PRMT5 (0.46) | BACE1NCF1NOS2 | |
| SCHEMBL3638928 | 0.72 | PIK3CD (0.42) | PLAUBACE1NOS2 | |
| SCHEMBL2928822 | 0.70 | BCHE (0.46) | BACE1NCF1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1066286-A4 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-02-11 | — | — | EP | claimed |
| EP-1066286-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-10 | — | — | EP | claimed |
| WO-1999045009-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-10 | — | — | WO | claimed |