Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13976245 | 0.87 | — | — | |
| SCHEMBL16160748 | 0.87 | CA2 (0.40) | CA1CA2GRIN1GRIN2BGRIN2D | |
| SCHEMBL17456540 | 0.85 | CA2 (0.39) | CA1CA2GRIN1GRIN2BGRIN2D | |
| SCHEMBL8772824 | 0.81 | CA1 (0.38) | CA1CA2GRIN1GRIN2BGRIN2D | |
| SCHEMBL17469919 | 0.77 | GRIN1 (0.41) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL3130594 | 0.77 | CA2 (0.54) | CA1CA2GRIN1GRIN2BGRIN2D | |
| SCHEMBL18631967 | 0.76 | GRIN1 (0.33) | CA1CA2GRIN1GRIN2BGRIN2D | |
| SCHEMBL5155129 | 0.75 | CA1 (0.58) | CA1CA2GRIN1GRIN2BCYP2C19 | |
| SCHEMBL11575485 | 0.75 | CA1 (0.58) | CA1CA2GRIN1GRIN2BCYP2C19 | |
| Ammonia Solution, Strong SCHEMBL27744923 | 0.73 | CA1 (0.56) | CA1CA2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401836-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF HERPES VIRAL INFECTIONS | SmithKline Beecham Corporation (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003000689-A1 | IMIDAZO`1,2-A!PYRIDINE DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF HERPES VIRAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-03 | — | — | WO | disclosed |