Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA3 | O75311 | 1/20 | 0.44 |
| ▸ | GLRB | P48167 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 5/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646087 | 0.90 | GLRA3 (0.44) | GLRA3GLRBSMN1; SMN2BACE1LTA4H | |
| SCHEMBL19928407 | 0.79 | GLRA3 (0.46) | GLRA3GLRBHDAC4LTA4HHCAR3 | |
| SCHEMBL6648461 | 0.79 | NAAA (0.46) | GLRA3GLRBSMN1; SMN2HTTHCAR3 | |
| SCHEMBL20256885 | 0.77 | GLRA3 (0.49) | GLRA3GLRBHDAC4LTA4HCREBBP | |
| SCHEMBL475508 | 0.77 | GLRA3 (0.70) | GLRA3GLRBHDAC4LTA4HTRPM4 | |
| SCHEMBL2207635 | 0.74 | BACE1 (0.44) | GLRA3GLRBSMN1; SMN2BACE1LTA4H | |
| SCHEMBL15131324 | 0.74 | GLRA3 (0.46) | GLRA3GLRBHDAC4LTA4HTRPM4 | |
| SCHEMBL2908806 | 0.73 | HTT (0.63) | SMN1; SMN2HTTTAS1R3TAS1R1 | |
| Hydrochloric Acid SCHEMBL6172352 | 0.73 | BACE1 (0.44) | GLRA3GLRBSMN1; SMN2BACE1LTA4H | |
| SCHEMBL3348971 | 0.73 | GLRA3 (0.41) | GLRA3GLRBBACE1LTA4HHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | disclosed |