Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.42 |
| ▸ | GLRB | P48167 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649704 | 0.82 | GLRA3 (0.41) | GLRA3GLRBXDHHCAR3 | |
| SCHEMBL17373856 | 0.79 | NAAA (0.68) | NAAASMN1; SMN2L3MBTL1GPR84MLYCD | |
| SCHEMBL17373956 | 0.79 | NAAA (0.68) | NAAASMN1; SMN2L3MBTL1GPR84MLYCD | |
| SCHEMBL6645786 | 0.79 | GLRA3 (0.44) | SMN1; SMN2GLRA3GLRBHCAR3HTT | |
| SCHEMBL6646087 | 0.79 | GLRA3 (0.44) | SMN1; SMN2GLRA3GLRBALDH1A1LMNA | |
| SCHEMBL6650208 | 0.77 | NAAA (0.46) | NAAAKDM5ASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL3358061 | 0.77 | LTA4H (0.40) | KDM5AGLRA3GLRBALDH1A1HPGD | |
| SCHEMBL20256885 | 0.76 | GLRA3 (0.49) | KDM5AGLRA3GLRBKDM4EALDH1A1 | |
| SCHEMBL475508 | 0.75 | GLRA3 (0.70) | GLRA3GLRBL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL2207635 | 0.75 | BACE1 (0.44) | SMN1; SMN2GLRA3GLRBL3MBTL1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | disclosed |