Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 5/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6647465 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBKCNE1CCR1KCNQ1 | |
| SCHEMBL6644829 | 0.87 | KCNE1 (0.44) | SMN1; SMN2POLBKCNE1CCR1KCNQ1 | |
| SCHEMBL5259936 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBKCNE1CCR1KCNQ1 | |
| SCHEMBL6647317 | 0.85 | ALDH1A1 (0.44) | SMN1; SMN2POLBERCC1FEN1ERCC4 | |
| Hydrochloric Acid SCHEMBL5255058 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBKCNE1CCR1KCNQ1 | |
| SCHEMBL5256631 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2POLBKCNE1CCR1KCNQ1 | |
| SCHEMBL5127309 | 0.84 | ERCC1 (0.46) | SMN1; SMN2POLBKCNE1CCR1KCNQ1 | |
| SCHEMBL6647080 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBKCNE1CCR1KCNQ1 | |
| SCHEMBL6646785 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBHTTHPGDL3MBTL1 | |
| SCHEMBL5253607 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2POLBKCNE1CCR1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035076-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | disclosed |