SCHEMBL6645878

SCHEMBL6645878

CN(C)C(Cc1nc(C(=O)NCc2ccc(F)cc2)c(CO)c(=O)[nH]1)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.41
ERCC1 P07992 1/20 0.41
FEN1 P39748 1/20 0.41
ERCC4 Q92889 1/20 0.41
LMNA P02545 1/20 0.39
KMT2A Q03164 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C19 P33261 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
HSD17B10 Q99714 1/20 0.38
EGLN1 Q9GZT9 1/20 0.38
HTT P42858 1/20 0.37
TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6645450 0.84 SMN1; SMN2 (0.42) ALDH1A1SMN1; SMN2ERCC1FEN1ERCC4
SCHEMBL5645281 0.81 ERCC1 (0.42) ALDH1A1SMN1; SMN2ERCC1FEN1ERCC4
SCHEMBL6649910 0.80 ERCC1 (0.41) ALDH1A1SMN1; SMN2ERCC1FEN1ERCC4
SCHEMBL6647885 0.75 SMN1; SMN2 (0.42) ALDH1A1SMN1; SMN2ERCC1FEN1ERCC4
SCHEMBL5201911 0.74 KCNE1 (0.47) ALDH1A1SMN1; SMN2ERCC1FEN1ERCC4
SCHEMBL6649380 0.73 ERCC1 (0.54) SMN1; SMN2ERCC1FEN1ERCC4EGLN1
SCHEMBL6650171 0.72 SMN1; SMN2 (0.41) SMN1; SMN2ERCC1FEN1ERCC4LMNA
SCHEMBL6883227 0.72 ERCC1 (0.47) ALDH1A1SMN1; SMN2ERCC1FEN1ERCC4
SCHEMBL6647968 0.72 SMN1; SMN2 (0.46) ALDH1A1SMN1; SMN2LMNAKMT2AKDM4E
SCHEMBL6646424 0.72 PARP1 (0.49) SMN1; SMN2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1441735-A1 N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) 2004-08-04 EP claimed
WO-2003035077-A1 N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2003-05-01 WO claimed
EP-1441735-A1 N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) 2004-08-04 EP disclosed
WO-2003035077-A1 N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2003-05-01 WO disclosed