Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5127792 | 0.79 | KMT2A (0.43) | SMN1; SMN2MEN1KMT2AATMNPSR1 | |
| SCHEMBL6645450 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2AERCC1FEN1 | |
| SCHEMBL1150329 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AATMNPSR1 | |
| SCHEMBL6647968 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2ANPSR1LMNAKDM4E | |
| SCHEMBL6645878 | 0.72 | ALDH1A1 (0.43) | SMN1; SMN2MEN1KMT2AERCC1FEN1 | |
| SCHEMBL6651068 | 0.70 | ERCC1 (0.52) | SMN1; SMN2ERCC1FEN1ERCC4 | |
| SCHEMBL5118543 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2AATMNPSR1 | |
| SCHEMBL6646424 | 0.69 | PARP1 (0.49) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5118888 | 0.69 | CALCA (0.45) | SMN1; SMN2MEN1KMT2AATMNPSR1 | |
| SCHEMBL5118805 | 0.69 | TP53 (0.46) | SMN1; SMN2MEN1KMT2AATMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441735-A1 | N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035077-A1 | N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | disclosed |