Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646151 | 0.88 | AKR1B1 (0.60) | AKR1B1KCNH2MEN1KMT2A | |
| SCHEMBL4451947 | 0.74 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL30889702 | 0.67 | KMT2A (0.46) | AKR1B1ALPGMAPTHTTRAB9A | |
| SCHEMBL6646351 | 0.66 | AKR1B1 (0.47) | AKR1B1ALPGMAPTHTTRAB9A | |
| SCHEMBL4570872 | 0.64 | NQO1 (0.57) | KCNH2ALPGMAPTHTTRAB9A | |
| SCHEMBL4454819 | 0.63 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL690925 | 0.63 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL27374058 | 0.61 | HCAR2 (0.38) | RAB9AALDH1A1HSD17B10NPC1 | |
| SCHEMBL6230934 | 0.60 | NOS1 (0.62) | ALPGMAPTHTTRAB9AKDM4E | |
| SCHEMBL29655018 | 0.60 | ALDH1A1 (0.56) | MAPTHTTRAB9ACA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373259-B1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PROD INC (US) | 2004-12-29 | — | — | EP | claimed |