Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648655 | 0.85 | KDM4E (0.71) | KMT2ALMNASMN1; SMN2TDP1RAB9A | |
| SCHEMBL14551142 | 0.83 | MAPT (0.73) | MAPTKMT2AMEN1LMNACYP1A2 | |
| SCHEMBL10273182 | 0.83 | KMT2A (0.51) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL7083568 | 0.81 | RAB9A (0.63) | MAPTKMT2AMEN1LMNACYP1A2 | |
| SCHEMBL6629035 | 0.78 | CYP19A1 (0.65) | MAPTKMT2AMEN1LMNACYP1A2 | |
| SCHEMBL6649613 | 0.75 | CYP19A1 (0.59) | MAPTKMT2ACYP1A2SMN1; SMN2TDP1 | |
| SCHEMBL4732492 | 0.74 | MAPT (0.52) | MAPTKMT2AMEN1LMNACYP1A2 | |
| SCHEMBL6650456 | 0.74 | RAB9A (0.52) | MAPTKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL6646978 | 0.74 | CYP19A1 (0.58) | MAPTKMT2ALMNACYP1A2SMN1; SMN2 | |
| SCHEMBL6648628 | 0.73 | CYP19A1 (0.60) | MAPTKMT2ALMNACYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |