Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 6/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198598 | 0.82 | TAAR1 (0.50) | TAAR1MEN1KMT2APTGES2AOC3 | |
| SCHEMBL27804764 | 0.80 | TAAR1 (0.48) | TAAR1MEN1KMT2APTGES2AOC3 | |
| SCHEMBL105528 | 0.80 | TAAR1 (0.48) | TAAR1MEN1KMT2APTGES2AOC3 | |
| SCHEMBL8113789 | 0.78 | RECQL (0.64) | TAAR1MEN1KMT2APTGES2AOC3 | |
| SCHEMBL29001383 | 0.78 | MGLL (0.47) | TAAR1MEN1KMT2APTGES2AOC3 | |
| SCHEMBL3135932 | 0.78 | TAAR1 (0.46) | TAAR1MEN1KMT2APTGES2CA12 | |
| SCHEMBL515211 | 0.77 | CA2 (0.53) | PTGES2CA12CA1CA2CA9 | |
| SCHEMBL2375914 | 0.77 | KMT2A (0.48) | TAAR1MEN1KMT2APTGES2CA12 | |
| SCHEMBL4704220 | 0.77 | TAAR1 (0.45) | TAAR1MEN1KMT2APTGES2CA12 | |
| SCHEMBL4704224 | 0.77 | TAAR1 (0.45) | TAAR1MEN1KMT2APTGES2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487801-A1 | 7-ARYLSULFONAMIDO-2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | claimed |
| WO-2003068751-A1 | 7-ARYLSULFONAMIDO-2,3,4,5-TETRAHYDRO-1H-BENZO'DIAZEPINE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY FOR THE REATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | claimed |