Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | USP10 | Q14694 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118623 | 0.91 | KMT2A (0.49) | KMT2AUSP10ALDH1A1MAPTRAB9A | |
| SCHEMBL4573533 | 0.84 | MAPT (0.49) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL30484131 | 0.83 | KMT2A (0.42) | KMT2AALDH1A1MAPTRAB9APKM | |
| SCHEMBL25300687 | 0.83 | KMT2A (0.42) | KMT2AALDH1A1MAPTRAB9APKM | |
| SCHEMBL7677183 | 0.79 | ALDH1A1 (0.56) | KMT2AALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL4082665 | 0.79 | ALDH1A1 (0.54) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL7028236 | 0.78 | MAPT (0.39) | KMT2AALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL2430950 | 0.77 | MAPT (0.52) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL18378212 | 0.76 | ALDH1A1 (0.45) | KMT2AALDH1A1MAPTPKMLMNA | |
| SCHEMBL3114745 | 0.76 | KMT2A (0.42) | KMT2AUSP10ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442039-A1 | PYRIMIDO (4,5-B) INDOLE DERIVATIVES | Bayer HealthCare AG (DE) | 2004-08-04 | — | — | EP | disclosed |
| WO-2004058764-A1 | 4-PHENYL-PYRIMIDO [4,5-B] INDOLE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2004-07-15 | — | — | WO | disclosed |
| WO-2003037898-A1 | PYRIMIDO [4,5-B] INDOLE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-05-08 | — | — | WO | disclosed |