Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645731 | 0.87 | KCNE1 (0.45) | KCNE1CCR1KCNQ1KMT2AMEN1 | |
| SCHEMBL6647470 | 0.85 | KCNE1 (0.44) | KCNE1CCR1KCNQ1KMT2AMEN1 | |
| SCHEMBL6647262 | 0.84 | MEN1 (0.43) | KCNE1CCR1KCNQ1KMT2AMEN1 | |
| SCHEMBL6648485 | 0.84 | KCNH2 (0.44) | KCNE1CCR1KCNQ1KMT2AMEN1 | |
| SCHEMBL5128003 | 0.80 | ALDH1A1 (0.50) | KCNE1CCR1KCNQ1KMT2AMEN1 | |
| SCHEMBL5116135 | 0.79 | POLB (0.44) | KCNE1CCR1KCNQ1KMT2AMEN1 | |
| SCHEMBL14609911 | 0.79 | ERCC1 (0.48) | KCNE1CCR1KCNQ1KMT2ALMNA | |
| SCHEMBL5122694 | 0.78 | KCNE1 (0.48) | KCNE1CCR1KCNQ1KMT2AMEN1 | |
| SCHEMBL6650692 | 0.78 | POLB (0.42) | KCNE1CCR1KCNQ1KMT2AMEN1 | |
| SCHEMBL5127309 | 0.78 | ERCC1 (0.46) | KCNE1CCR1KCNQ1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035076-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | disclosed |