Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762233 | 0.74 | CHRM2 (0.44) | CHRM2CHRM1CHRM3ALDH1A1TSHR | |
| SCHEMBL6648703 | 0.72 | SYK (0.40) | CHRM2CHRM1CHRM3EPHX2LTA4H | |
| SCHEMBL5757480 | 0.72 | HTT (0.40) | ALDH1A1TSHR | |
| SCHEMBL28197543 | 0.71 | CHRM2 (0.38) | CHRM2CHRM1CHRM3EPHX2 | |
| SCHEMBL5615358 | 0.69 | PDPK1 (0.47) | ALDH1A1TSHRLTA4H | |
| SCHEMBL3626364 | 0.69 | — | — | |
| SCHEMBL27979786 | 0.69 | — | — | |
| SCHEMBL6646476 | 0.68 | CHRM2 (0.33) | CHRM2CHRM1CHRM3ALDH1A1TSHR | |
| SCHEMBL11823932 | 0.68 | TDP1 (0.43) | CHRM2CHRM1CHRM3ALDH1A1TSHR | |
| Bromide SCHEMBL27458288 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465862-A1 | CYCLOALKYL KETOAMIDES DERIVATIVES USEFUL AS CATHEPSIN K INHIBITORS | SmithKline Beecham Corporation (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003062192-A1 | CYCLOALKYL KETOAMIDES DERIVATIVES USEFUL AS CATHEPSIN K INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-07-31 | — | — | WO | disclosed |