Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SREBF2 | Q12772 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649838 | 0.86 | KDM4E (0.59) | RAB9ANPC1KDM4EALDH1A1SREBF2 | |
| SCHEMBL6648190 | 0.85 | KDM4E (0.52) | RAB9ANPC1KDM4EALDH1A1SREBF2 | |
| SCHEMBL6648508 | 0.85 | KDM4E (0.51) | RAB9ANPC1KDM4EALDH1A1SREBF2 | |
| SCHEMBL6647164 | 0.84 | KDM4E (0.59) | RAB9ANPC1KDM4EALDH1A1SREBF2 | |
| SCHEMBL6649085 | 0.84 | KDM4E (0.59) | RAB9ANPC1KDM4EALDH1A1SREBF2 | |
| SCHEMBL6649816 | 0.83 | CDC25A (0.55) | RAB9ANPC1KDM4EALDH1A1SREBF2 | |
| SCHEMBL6647985 | 0.83 | RAB9A (0.64) | RAB9ANPC1KDM4EALDH1A1MAPK1 | |
| SCHEMBL6654411 | 0.82 | CYP19A1 (0.55) | RAB9ANPC1KDM4EALDH1A1SREBF2 | |
| SCHEMBL6649374 | 0.81 | SREBF2 (0.59) | RAB9ANPC1KDM4EALDH1A1MAPK1 | |
| SCHEMBL6650443 | 0.81 | SREBF2 (0.55) | RAB9ANPC1KDM4EALDH1A1SREBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |