Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 17/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.55 |
| ▸ | GAA | P10253 | 11/20 | 0.55 |
| ▸ | HPGD | P15428 | 9/20 | 0.55 |
| ▸ | GLA | P06280 | 7/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | CASP1 | P29466 | 4/20 | 0.55 |
| ▸ | CASP7 | P55210 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353464 | 0.88 | MAPT (0.68) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL13481991 | 0.87 | MAPT (0.66) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL670503 | 0.83 | MAPT (0.61) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL25857513 | 0.82 | MAPT (0.43) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL1146916 | 0.78 | MAPT (1.00) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL11904084 | 0.78 | MAPT (0.67) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL12478278 | 0.78 | ALDH1A1 (0.66) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL8329505 | 0.77 | MAPT (0.57) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL4508858 | 0.77 | HDAC3 (0.58) | KDM4EKMT2AATM | |
| SCHEMBL68892 | 0.76 | MAPT (0.69) | MAPTKDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | claimed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | claimed |