Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743630 | 0.83 | ALOX5 (0.35) | MAPK1P2RX4NPC1TDP1CHRM2 | |
| SCHEMBL4747072 | 0.83 | ALOX5 (0.35) | P2RX4TDP1CHRM2CHRM1CHRM3 | |
| SCHEMBL5863624 | 0.83 | ALOX5 (0.35) | P2RX4TDP1CHRM2CHRM1CHRM3 | |
| SCHEMBL6650659 | 0.83 | HDAC1 (0.46) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL6648251 | 0.83 | P2RX4 (0.40) | HDAC1HDAC8P2RX4NPC1RAB9A | |
| SCHEMBL6766394 | 0.82 | P2RX4 (0.34) | P2RX4TDP1CHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL6766830 | 0.81 | ALOX5 (0.33) | P2RX4TDP1CHRM2CHRM1CHRM3 | |
| SCHEMBL6647945 | 0.81 | EPHX2 (0.43) | P2RX4NPC1RAB9AEPHX2L3MBTL1 | |
| SCHEMBL4669217 | 0.79 | P2RX4 (0.40) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL523372 | 0.77 | ALOX5 (0.39) | P2RX4TDP1CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904262-B1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2004-04-21 | — | — | EP | disclosed |
| US-6472414-B1 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-29 | — | — | US | disclosed |
| EP-0904262-A4 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-0904262-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5760246-A | ANTILIPEMIC AGENTS, ANTICHOLESTEROL AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 1998-06-02 | — | — | US | disclosed |
| WO-1997026240-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-07-24 | — | — | WO | disclosed |