SCHEMBL6650376

SCHEMBL6650376

Cc1cc(CNC2CCCO2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPA5 P11021 2/20 0.50
CYP2C9 P11712 3/20 0.49
CYP2C19 P33261 3/20 0.49
HIF1A Q16665 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
CYP2D6 P10635 3/20 0.45
HSD17B10 Q99714 1/20 0.45
ALDH1A1 P00352 5/20 0.42
POLB P06746 2/20 0.42
CA2 P00918 1/20 0.42
TYR P14679 1/20 0.42
CYP1A2 P05177 1/20 0.42
TSHR P16473 1/20 0.37
GAA P10253 3/20 0.34
HTT P42858 2/20 0.34
XBP1 P17861 1/20 0.34
MAPK1 P28482 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
HPGD P15428 2/20 0.33
PABPC1 P11940 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6649318 0.97 HSPA5 (0.48) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL6649041 0.96 HSPA5 (0.49) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL6653608 0.87 CYP2C19 (0.51) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL12309149 0.79 HSPA5 (0.53) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL8429713 0.78 HSPA5 (0.48) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL6653839 0.77 HSPA5 (0.54) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL9033353 0.76 HSPA5 (0.53) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL10040348 0.76 CYP2C19 (0.56) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL16442482 0.74 HSPA5 (0.47) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL9048995 0.72 HSPA5 (0.50) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0741731-B1 PROCESS FOR EPOXIDISING PROCHIRAL OLEFINS SMITHKLINE BEECHAM PLC (GB) 2004-04-07 EP disclosed
US-6211107-B1 Process for expoxidizing prochiral olefins and a catalyst therefor and intermediates for making the catalyst SMITHKLINE BEECHAM P.L.C. (GB) 2001-04-03 US disclosed
US-5616750-A Compounds and process SMITHKLINE BEECHAM PLC (GB) 1997-04-01 US disclosed
EP-0655950-B1 CHIRAL CATALYSTS AND EPOXIDATION REACTIONS CATALYZED THEREBY SMITHKLINE BEECHAM PLC (GB) 1996-10-23 EP disclosed