SCHEMBL6653608

SCHEMBL6653608

CC(C)(C)c1cc(CNC2CCCO2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 6/20 0.51
CYP2D6 P10635 4/20 0.51
CYP2C9 P11712 4/20 0.51
CYP1A2 P05177 4/20 0.51
ALDH1A1 P00352 4/20 0.47
TSHR P16473 3/20 0.47
HTT P42858 3/20 0.47
GAA P10253 2/20 0.47
XBP1 P17861 1/20 0.47
MAPK1 P28482 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
HSD17B10 Q99714 1/20 0.36
KDM4E B2RXH2 1/20 0.34
HSPA5 P11021 2/20 0.34
NR5A2 O00482 1/20 0.34
NR5A1 Q13285 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
CYP3A4 P08684 1/20 0.33
PABPC1 P11940 1/20 0.33
HIF1A Q16665 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6650376 0.87 HSPA5 (0.50) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
Hydrochloric Acid SCHEMBL6649318 0.85 HSPA5 (0.48) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
SCHEMBL6649041 0.84 HSPA5 (0.49) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
SCHEMBL663756 0.81 CYP2C19 (0.59) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
SCHEMBL5673666 0.81 CYP2C19 (0.59) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
SCHEMBL1881392 0.81 CYP2C19 (0.59) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
SCHEMBL663757 0.81 CYP2C19 (0.59) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
SCHEMBL8783194 0.80 CYP2C19 (0.58) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
SCHEMBL6057504 0.80 CYP2C19 (0.78) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1
SCHEMBL30874729 0.80 CYP2C19 (0.58) CYP2C19CYP2D6CYP2C9CYP1A2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0741731-B1 PROCESS FOR EPOXIDISING PROCHIRAL OLEFINS SMITHKLINE BEECHAM PLC (GB) 2004-04-07 EP disclosed
US-6211107-B1 Process for expoxidizing prochiral olefins and a catalyst therefor and intermediates for making the catalyst SMITHKLINE BEECHAM P.L.C. (GB) 2001-04-03 US disclosed
US-5616750-A Compounds and process SMITHKLINE BEECHAM PLC (GB) 1997-04-01 US disclosed
EP-0741731-A1 PROCESS FOR EPOXIDISING PROCHIRAL OLEFINS AND A CATALYST THEREFOR AND INTERMEDIATES FOR MAKING THE CATALYST SMITHKLINE BEECHAM PLC (GB) 1996-11-13 EP disclosed
EP-0655950-B1 CHIRAL CATALYSTS AND EPOXIDATION REACTIONS CATALYZED THEREBY SMITHKLINE BEECHAM PLC (GB) 1996-10-23 EP disclosed
WO-1995021172-A1 PROCESS FOR EPOXIDISING PROCHIRAL OLEFINS AND A CATALYST THEREFOR AND INTERMEDIATES FOR MAKING THE CATALYST SMITHKLINE BEECHAM P.L.C. (GB) 1995-08-10 WO disclosed