Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.92 |
| ▸ | HTR1D | P28221 | 19/20 | 0.92 |
| ▸ | HTR1B | P28222 | 17/20 | 0.92 |
| ▸ | HTR7 | P34969 | 7/20 | 0.72 |
| ▸ | DRD3 | P35462 | 7/20 | 0.72 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.72 |
| ▸ | DRD2 | P14416 | 6/20 | 0.72 |
| ▸ | HTR2A | P28223 | 5/20 | 0.72 |
| ▸ | HTR2B | P41595 | 4/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.72 |
| ▸ | HTR2C | P28335 | 4/20 | 0.62 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216805 | 0.96 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL5213744 | 0.94 | HTR1A (0.85) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL6651421 | 0.91 | HTR1A (0.76) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL14565044 | 0.86 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL14564979 | 0.85 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL29388787 | 0.84 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL5364247 | 0.84 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL29462269 | 0.81 | HTR1D (0.93) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL5220139 | 0.79 | HTR1A (0.85) | HTR1AHTR1DHTR1BHTR7DRD3 | |
| SCHEMBL5251500 | 0.79 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476444-A1 | HETEROCYCLIC COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY | GLAXO GROUP LIMITED (GB) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003068772-A1 | HETEROCYCLIC COMPOUNDS POSSESSING AFFINITY AT 5HT1-TYPE RECEPTORS AND USE THEREOF IN THERAPY | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |