SCHEMBL6651618

SCHEMBL6651618

CN1CCCCC1CO.Cc1[nH]c2ccc(OCC3CCCCN3C)cc2c1C(=O)OCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.49
MCHR1 Q99705 2/20 0.49
CHRNB2 P17787 5/20 0.49
CHRNA4 P43681 4/20 0.49
CHRNA7 P36544 3/20 0.49
CHRNA5 P30532 2/20 0.49
KDM4E B2RXH2 2/20 0.45
GAA P10253 1/20 0.45
CHRNB4 P30926 3/20 0.43
CHRNA3 P32297 3/20 0.43
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
HSD17B10 Q99714 1/20 0.42
SPHK2 Q9NRA0 1/20 0.40
CHRNB1 P11230 1/20 0.40
CHRNB3 Q05901 1/20 0.40
JAK2 O60674 1/20 0.40
CHRM2 P08172 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6314845 0.97 CHRNB2 (0.52) KCNH2MCHR1CHRNB2CHRNA4CHRNA7
SCHEMBL6651622 0.85 KDM4E (0.41) KCNH2MCHR1CHRNB2CHRNA4CHRNA7
SCHEMBL6316638 0.82 MAOA (0.45) CHRNB2CHRNA4CHRNA7CHRNA5KDM4E
SCHEMBL6316855 0.80 HTT (0.53) KCNH2MCHR1KDM4ELMNAMAPT
SCHEMBL6314855 0.80 NPC1 (0.54) KDM4EHTTALDH1A1
SCHEMBL6321908 0.80 HTT (0.53) KCNH2MCHR1KDM4EHTTALDH1A1
SCHEMBL6316318 0.80 HTT (0.53) KCNH2MCHR1KDM4EHTTALDH1A1
SCHEMBL6323878 0.79 KDM4E (0.55) KDM4EHTTALDH1A1
SCHEMBL6323053 0.78 SPHK1 (0.44) MCHR1KDM4EGAALMNASPHK2
SCHEMBL6323062 0.78 SPHK1 (0.44) MCHR1KDM4EGAALMNASPHK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1377549-A1 FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR Millennium Pharmaceuticals, Inc. (US) 2004-01-07 EP disclosed
WO-2002072549-A1 FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR MILLENNIUM PHARMACEUTICALS, INC. (US) 2002-09-19 WO disclosed