Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | AR | P10275 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | EIF4E | P06730 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | CDC25C | P30307 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646252 | 0.87 | CYP19A1 (0.55) | RAB9AKDM4ESMN1; SMN2ARLMNA | |
| SCHEMBL6649581 | 0.86 | EIF4E (0.60) | RAB9AKDM4EARCYP19A1RPS6KA3 | |
| SCHEMBL6649680 | 0.85 | KDM4E (0.62) | RAB9AKDM4ESMN1; SMN2ARLMNA | |
| SCHEMBL6649689 | 0.84 | AR (0.57) | RAB9AKDM4EARCYP19A1RPS6KA3 | |
| SCHEMBL6628622 | 0.82 | CYP19A1 (0.59) | RAB9AKDM4EARCYP19A1RPS6KA3 | |
| SCHEMBL3813712 | 0.82 | KDM4E (0.69) | RAB9AKDM4ESMN1; SMN2ARLMNA | |
| SCHEMBL6650065 | 0.82 | KDM4E (0.54) | RAB9AKDM4ESMN1; SMN2ARLMNA | |
| SCHEMBL11456620 | 0.81 | KDM4E (0.73) | RAB9AKDM4ESMN1; SMN2ARLMNA | |
| SCHEMBL28495695 | 0.81 | KDM4E (0.73) | RAB9AKDM4ESMN1; SMN2ARLMNA | |
| SCHEMBL3814593 | 0.80 | KDM4E (0.66) | RAB9AKDM4ESMN1; SMN2ARLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |