Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | GCGR | P47871 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628622 | 0.89 | CYP19A1 (0.59) | CYP19A1RAB9ANPC1KDM4EAR | |
| SCHEMBL6651736 | 0.87 | RAB9A (0.61) | CYP19A1RAB9ANPC1KDM4EAR | |
| SCHEMBL6649581 | 0.86 | EIF4E (0.60) | CYP19A1RAB9ANPC1KDM4EAR | |
| SCHEMBL6646582 | 0.81 | CYP19A1 (0.60) | CYP19A1RAB9ANPC1KDM4EMAPT | |
| SCHEMBL6646768 | 0.78 | CYP19A1 (0.56) | CYP19A1RAB9ANPC1MAPTGLA | |
| SCHEMBL6649680 | 0.77 | KDM4E (0.62) | CYP19A1RAB9ANPC1KDM4EAR | |
| SCHEMBL6654411 | 0.77 | CYP19A1 (0.55) | CYP19A1RAB9ANPC1KDM4EMAPT | |
| SCHEMBL6649689 | 0.76 | AR (0.57) | CYP19A1RAB9AKDM4EARGCGR | |
| SCHEMBL6650456 | 0.76 | RAB9A (0.52) | CYP19A1RAB9ANPC1KDM4EAR | |
| SCHEMBL6648655 | 0.76 | KDM4E (0.71) | CYP19A1RAB9ANPC1KDM4EAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444228-A2 | SUBSTITUTED HETEROARYLALKANOIC ACIDS AND THEIR USE AS ALDOSE REDUCTASE INHIBITORS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003044015-A2 | SUBSTITUTED HETEROARYLALKANOIC ACIDS AND THEIR USE AS ALDOSE REDUCTASE INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2003-05-30 | — | — | WO | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |