Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 15/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6651736 | 0.86 | RAB9A (0.61) | EIF4ERPS6KA3KDM4EARCYP19A1 | |
| SCHEMBL6646252 | 0.86 | CYP19A1 (0.55) | EIF4ERPS6KA3KDM4EARCYP19A1 | |
| SCHEMBL6628622 | 0.84 | CYP19A1 (0.59) | RPS6KA3KDM4EARCYP19A1MEN1 | |
| SCHEMBL6649024 | 0.81 | EIF4E (0.64) | EIF4EKDM4ECYP19A1MEN1NPC1 | |
| SCHEMBL14797442 | 0.80 | EIF4E (0.69) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL6649680 | 0.79 | KDM4E (0.62) | RPS6KA3KDM4EARCYP19A1MEN1 | |
| SCHEMBL14797397 | 0.79 | EIF4E (0.71) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL6649689 | 0.78 | AR (0.57) | EIF4ERPS6KA3KDM4EARCYP19A1 | |
| SCHEMBL6648675 | 0.78 | EIF4E (0.58) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL6648869 | 0.78 | EIF4E (0.55) | EIF4EKDM4EMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |