Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11798862 | 0.87 | MAPK13 (0.72) | ALDH1A1GAATDP1ALOX15HTT | |
| SCHEMBL6656529 | 0.84 | MAPK13 (0.60) | ALDH1A1GAAMAPK13MAPK12MAPK11 | |
| SCHEMBL6656304 | 0.84 | MAPT (0.61) | ALDH1A1GAATDP1ALOX15HTT | |
| SCHEMBL6653594 | 0.82 | MAPK13 (0.70) | ALDH1A1GAAALOX15HTTMAPK13 | |
| SCHEMBL15968528 | 0.82 | GAA (1.00) | ALDH1A1GAATDP1ALOX15HTT | |
| SCHEMBL2789324 | 0.81 | MAPK13 (0.78) | ALDH1A1TDP1HTTMAPK13MAPK12 | |
| SCHEMBL2791237 | 0.81 | MAPK13 (0.78) | ALDH1A1TDP1HTTMAPK13MAPK12 | |
| SCHEMBL6655626 | 0.81 | MAPK13 (0.56) | ALDH1A1GAATDP1ALOX15HTT | |
| SCHEMBL6657520 | 0.80 | CTSV (0.56) | ALDH1A1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL27483181 | 0.78 | MAPK13 (0.64) | ALDH1A1GAAALOX15MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188388-C | Aminobenzophenones as inhibitors of interleukin and TNF | LEO PHARM PROD LTD (DK) | 2005-02-09 | — | — | CN | disclosed |
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |