Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 11/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 11/20 | 0.57 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127855 | 0.88 | AKR1C3 (0.62) | AKR1C3AKR1C2KDM4EALDH1A1GAA | |
| SCHEMBL11798862 | 0.85 | MAPK13 (0.72) | MAPK13MAPK12MAPK11MAPK14DHODH | |
| SCHEMBL6652677 | 0.84 | ALDH1A1 (0.69) | MAPK13MAPK12MAPK11MAPK14DHODH | |
| SCHEMBL6656304 | 0.83 | MAPT (0.61) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL27496499 | 0.83 | AKR1C3 (0.49) | AKR1C3AKR1C2KDM4EALDH1A1GAA | |
| SCHEMBL6653594 | 0.81 | MAPK13 (0.70) | MAPK13MAPK12MAPK11MAPK14KDM4E | |
| SCHEMBL11419839 | 0.81 | AKR1C3 (0.65) | AKR1C3AKR1C2DHODHKDM4EALDH1A1 | |
| SCHEMBL11417902 | 0.81 | AKR1C3 (0.67) | AKR1C3AKR1C2DHODHKDM4EALDH1A1 | |
| SCHEMBL2789324 | 0.80 | MAPK13 (0.78) | MAPK13MAPK12MAPK11MAPK14DHODH | |
| SCHEMBL2791237 | 0.80 | MAPK13 (0.78) | MAPK13MAPK12MAPK11MAPK14DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |