SCHEMBL6652697

SCHEMBL6652697

N#Cc1ccc(Nc2c(F)c3c(c(F)c2Nc2ccc(C#N)cc2)C(=O)c2ccccc2C3=O)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.44
TOP2A P11388 1/20 0.43
TOP2B Q02880 1/20 0.43
CXCR2 P25025 2/20 0.43
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
SYK P43405 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
DHODH Q02127 1/20 0.39
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
EGFR P00533 1/20 0.39
KDR P35968 1/20 0.39
MAOB P27338 1/20 0.39
SLC22A12 Q96S37 1/20 0.38
ABCG2 Q9UNQ0 3/20 0.38
ABCB1 P08183 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6654379 0.94 MAPT (0.42) MAPTTOP2ATOP2BCXCR2CA1
SCHEMBL6652975 0.91 MAPT (0.41) MAPTTOP2ATOP2BCXCR2CA1
SCHEMBL6652507 0.86 STK10 (0.39) MAPTTOP2ATOP2BCXCR2CA1
SCHEMBL6652518 0.85 MAPT (0.34) MAPTTOP2ATOP2BCXCR2CA1
SCHEMBL6652520 0.83 USP8 (0.41) MAPTTOP2ATOP2BCXCR2SYK
SCHEMBL21816966 0.82 MAPT (0.54) MAPTCXCR2MEN1KMT2ADHODH
SCHEMBL7933227 0.82 CXCR2 (0.46) MAPTTOP2ATOP2BCXCR2CA1
SCHEMBL6653689 0.82 USP8 (0.45) MAPTMEN1KMT2ADHODHCASP3
SCHEMBL6652489 0.82 MAPT (0.34) MAPTTOP2ATOP2BCXCR2DHODH
SCHEMBL21817082 0.80 STK10 (0.48) CXCR2SYKKDRMAOBSLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0833203-B1 Anthraquinone compounds NIPPON CATALYTIC CHEM IND (JP) 2004-06-16 EP disclosed
US-5968688-A RESINS AND DYES FOR COLOR FILTERS NIPPON SHOKUBAI CO., LTD. (JP) 1999-10-19 US disclosed
EP-0833203-A1 Color filter grade photosensitive resin coloring composition, and color filter using the same NIPPON SHOKUBAI CO., LTD. (JP) 1998-04-01 EP disclosed