Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6652737 | 1.00 | OPRD1 (0.51) | OPRD1ATMCYP3A4USP2CYP2D6 | |
| SCHEMBL6658983 | 0.88 | HRH1 (0.52) | OPRD1ATMCYP3A4USP2CYP2D6 | |
| SCHEMBL6658977 | 0.88 | HRH1 (0.52) | OPRD1ATMCYP3A4USP2CYP2D6 | |
| SCHEMBL6658996 | 0.88 | HRH1 (0.52) | OPRD1ATMCYP3A4USP2CYP2D6 | |
| SCHEMBL6656936 | 0.88 | OPRD1 (0.44) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6656946 | 0.88 | OPRD1 (0.44) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6654609 | 0.85 | OPRD1 (0.53) | OPRD1ATMCYP3A4USP2CYP2D6 | |
| SCHEMBL6654611 | 0.85 | OPRD1 (0.53) | OPRD1ATMCYP3A4USP2CYP2D6 | |
| SCHEMBL6651771 | 0.82 | OPRD1 (0.54) | OPRD1ATMCYP3A4USP2CYP2D6 | |
| SCHEMBL6651777 | 0.82 | OPRD1 (0.54) | OPRD1ATMCYP3A4USP2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983251-B1 | ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF | PFIZER LTD (GB) | 2004-06-23 | — | — | EP | disclosed |
| US-6514975-B1 | Tetrazoles as selective agonists for the delta opioid receptor | PFIZER INC | 2003-02-04 | — | — | US | disclosed |