Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314840 | 0.97 | KDM4E (0.48) | KDM4EMAOBMAOABCHEACHE | |
| SCHEMBL6316855 | 0.88 | HTT (0.53) | KDM4ELTA4HLMNAMAPTHPGD | |
| SCHEMBL6314661 | 0.88 | GAA (0.50) | KDM4EMAOBMAOAMEN1KMT2A | |
| SCHEMBL6316318 | 0.87 | HTT (0.53) | KDM4ELTA4HHTTPARP1 | |
| SCHEMBL6323166 | 0.87 | KDM4E (0.48) | KDM4EMAOBMAOALTA4HPDE3B | |
| SCHEMBL6321908 | 0.87 | HTT (0.53) | KDM4ELTA4HHTTPARP1 | |
| SCHEMBL6317111 | 0.87 | KDM4E (0.52) | KDM4EMAOBMAOABCHEACHE | |
| SCHEMBL6316727 | 0.86 | LTA4H (0.48) | KDM4ELTA4HLMNAMAPTHPGD | |
| SCHEMBL6650428 | 0.86 | MAOB (0.41) | KDM4EMAOBMAOABCHEACHE | |
| SCHEMBL6316010 | 0.86 | PARP1 (0.48) | KDM4EMAOBMAOABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002072549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-09-19 | — | — | WO | disclosed |