Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320566 | 0.97 | MAOB (0.41) | MAOBMAOABCHEACHEKDM4E | |
| SCHEMBL6323073 | 0.90 | KDM4E (0.43) | MAOBMAOABCHEACHEKDM4E | |
| SCHEMBL6652976 | 0.86 | KDM4E (0.46) | MAOBMAOABCHEACHEKDM4E | |
| SCHEMBL6315844 | 0.86 | OPRM1 (0.41) | LTA4HCCR5 | |
| SCHEMBL6317111 | 0.85 | KDM4E (0.52) | MAOBMAOABCHEACHEKDM4E | |
| SCHEMBL6316010 | 0.84 | PARP1 (0.48) | MAOBMAOABCHEACHEKDM4E | |
| SCHEMBL6322012 | 0.83 | LTA4H (0.48) | MAOBMAOABCHEACHEKDM4E | |
| Hydrochloric Acid SCHEMBL6316093 | 0.83 | PARP1 (0.47) | MAOBMAOABCHEACHEKDM4E | |
| SCHEMBL6318493 | 0.83 | LTA4H (0.48) | MAOBMAOABCHEACHEKDM4E | |
| SCHEMBL6316336 | 0.83 | LTA4H (0.48) | MAOBMAOABCHEACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002072549-A1 | FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-09-19 | — | — | WO | disclosed |