Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6729089 | 0.99 | KDM4E (0.52) | KDM4ESMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL6651402 | 0.80 | LMNA (0.52) | KDM4ESMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4096057 | 0.79 | EGFR (0.53) | KDM4ESMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL19692566 | 0.76 | SIGMAR1 (0.72) | HRH3 | |
| SCHEMBL7787081 | 0.76 | KMT2A (0.63) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6721658 | 0.75 | KMT2A (0.62) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6728460 | 0.75 | BCHE (0.49) | KDM4ESMN1; SMN2 | |
| SCHEMBL24163546 | 0.73 | KDM4E (0.70) | KDM4ELMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL6652158 | 0.72 | HRH3 (0.51) | KDM4EALDH1A1HRH3 | |
| Hydrochloric Acid SCHEMBL6728490 | 0.71 | HRH3 (0.50) | KDM4EALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143971-B1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PF MEDICAMENT (FR) | 2004-06-02 | — | — | EP | disclosed |
| EP-1143971-A1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PIERRE FABRE MEDICAMENT (FR) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043011-A1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PIERRE FABRE MEDICAMENT (FR) | 2000-07-27 | — | — | WO | disclosed |