SCHEMBL6652987

SCHEMBL6652987

CC(=O)c1c(Cl)cc(C)nc1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.45
ALDH1A1 P00352 5/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
MAPK1 P28482 1/20 0.44
POLB P06746 2/20 0.43
KDM4E B2RXH2 5/20 0.41
LMNA P02545 2/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
MAPT P10636 1/20 0.41
MEN1 O00255 1/20 0.41
PKM P14618 1/20 0.41
NPSR1 Q6W5P4 1/20 0.39
TP53 P04637 1/20 0.39
HSD17B10 Q99714 1/20 0.39
HTT P42858 2/20 0.38
DHODH Q02127 1/20 0.37
GAA P10253 1/20 0.36
ALOX15 P16050 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17084212 0.84 KMT2A (0.45) KMT2AALDH1A1SMN1; SMN2MAPK1POLB
SCHEMBL7706726 0.84 SMN1; SMN2 (0.58) KMT2AALDH1A1SMN1; SMN2MAPK1POLB
SCHEMBL900419 0.84 ALDH1A1 (0.58) KMT2AALDH1A1SMN1; SMN2MAPK1POLB
SCHEMBL31369008 0.81 KMT2A (0.50) KMT2AALDH1A1SMN1; SMN2MAPK1POLB
SCHEMBL900397 0.79 KMT2A (0.41) KMT2AALDH1A1SMN1; SMN2MAPK1POLB
SCHEMBL2381068 0.79 ALDH1A1 (0.52) KMT2AALDH1A1SMN1; SMN2MAPK1POLB
SCHEMBL3177622 0.78 KMT2A (0.41) KMT2AALDH1A1SMN1; SMN2KDM4ELMNA
SCHEMBL15316168 0.78 KMT2A (0.50) KMT2AALDH1A1SMN1; SMN2MAPK1POLB
SCHEMBL3183945 0.77 HTT (0.50) KMT2AALDH1A1SMN1; SMN2MAPK1KDM4E
SCHEMBL3179849 0.77 ALDH1A1 (0.46) KMT2AALDH1A1SMN1; SMN2MAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218401-B1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE AVENTIS PHARMA GMBH (DE) 2004-06-16 EP disclosed
EP-1218401-A1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE Aventis Pharma Deutschland GmbH (DE) 2002-07-03 EP disclosed
US-6339077-B1 FOR PROPHYLAXIS OR OF GALLSTONES AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-01-15 US disclosed
WO-2001021642-A1 4-BENZYLAMINOQUINOLINE CONJUGATES WITH BILE ACID AND THEIR HETEROANALOGUES, METHODS FOR PRODUCING THE SAME, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-03-29 WO disclosed