Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031540 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL3227278 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL30593189 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL6652987 | 0.84 | KMT2A (0.45) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL19212155 | 0.82 | POLB (0.76) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL7709595 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL2630833 | 0.79 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL6849011 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL26608490 | 0.78 | POLB (0.54) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A | |
| SCHEMBL5871852 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1MAPK1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130267513-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2013-10-10 | — | — | US | disclosed |
| US-20130267513-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2013-10-10 | — | — | US | disclosed |
| WO-2011141756-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267513-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | LRRK2, PARK7, GRK3 | SMN1; SMN2 1043/4885ALDH1A1 4327/4885MAPK1 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.