Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.66 |
| ▸ | CES2 | O00748 | 2/20 | 0.59 |
| ▸ | CES1 | P23141 | 2/20 | 0.59 |
| ▸ | KIF11 | P52732 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648641 | 0.89 | SRD5A2 (0.83) | SRD5A2CES2CES1EPHX2GSK3B | |
| Hydrochloric Acid SCHEMBL27733522 | 0.87 | SRD5A2 (0.79) | SRD5A2CES2CES1EPHX2GSK3B | |
| SCHEMBL8762089 | 0.84 | PTGS1 (0.49) | SRD5A2PTGS1CES2CES1KIF11 | |
| SCHEMBL13410662 | 0.83 | SRD5A2 (0.73) | SRD5A2CES2CES1KIF11EPHX2 | |
| SCHEMBL28000964 | 0.83 | SRD5A2 (0.73) | SRD5A2CES2CES1KIF11EPHX2 | |
| SCHEMBL4979512 | 0.82 | SRD5A2 (0.73) | SRD5A2PTGS1CES2 | |
| SCHEMBL30438832 | 0.82 | KIF11 (0.84) | PTGS1CES2CES1KIF11 | |
| SCHEMBL27948267 | 0.82 | KIF11 (0.84) | PTGS1CES2CES1KIF11 | |
| SCHEMBL10302 | 0.82 | KIF11 (0.84) | PTGS1CES2CES1KIF11 | |
| SCHEMBL9097535 | 0.82 | CA12 (0.59) | SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |
| EP-0966424-A1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998032730-A1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-07-30 | — | — | WO | disclosed |
| EP-0012435-A2 | Isoxazole derivatives, process for their preparation, medicines containing them and intermediates required in this process | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-06-25 | — | — | EP | disclosed |
| US-4026697-A | HERBICIDES | AMERICAN CYANAMID COMPANY (US) | 1977-05-31 | — | — | US | disclosed |
| US-3988300-A | FOR CONTROLLING BROADLEAF WEEDS AND GRASSES | AMERICAN CYANAMID COMPANY (US) | 1976-10-26 | — | — | US | disclosed |