Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30708157 | 1.00 | CYP11B2 (0.65) | CYP11B2CYP11B1KDM4ELRRK2SMO | |
| SCHEMBL30270004 | 0.83 | KDM4E (0.56) | CYP11B2CYP11B1KDM4ELRRK2HTT | |
| SCHEMBL729956 | 0.83 | KDM4E (0.56) | CYP11B2CYP11B1KDM4ELRRK2HTT | |
| SCHEMBL29741044 | 0.81 | CYP11B2 (0.51) | CYP11B2CYP11B1KDM4ELRRK2SMO | |
| SCHEMBL29741071 | 0.81 | CYP11B2 (0.55) | CYP11B2CYP11B1KDM4ELRRK2GAA | |
| Hydrochloric Acid SCHEMBL3379409 | 0.81 | KDM4E (0.55) | CYP11B2CYP11B1KDM4ELRRK2HTT | |
| SCHEMBL15839063 | 0.79 | CYP11B2 (0.78) | CYP11B2CYP11B1LRRK2SMOKHK | |
| SCHEMBL15825125 | 0.79 | CYP11B2 (0.69) | CYP11B2CYP11B1SMOMAPK1 | |
| SCHEMBL413216 | 0.79 | CYP11B2 (0.69) | CYP11B2CYP11B1SMOCYP2A6MAPK1 | |
| SCHEMBL15839046 | 0.79 | CYP11B2 (1.00) | CYP11B2CYP11B1SMOCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2934144-B1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-07-19 | — | — | EP | claimed |
| US-9522141-B2 | Indazole compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-12-20 | — | — | US | claimed |
| US-20150320733-A1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-11-12 | — | — | US | claimed |
| EP-2934144-B1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-07-19 | — | — | EP | disclosed |
| US-9522141-B2 | Indazole compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-12-20 | — | — | US | disclosed |
| US-20150320733-A1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-11-12 | — | — | US | disclosed |
| EP-1432698-A2 | SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | disclosed |
| WO-2003027094-A2 | SUBSTITUTED 3-PYRIDYL INDOLES AND INDAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
| CN-1305462-A | 1,5 and 3-O-substituted 1H-indazoles with antiasthmatic, antiallergic, antiinflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments | DRESDEN ARZNEIMITTEL (DE) | 2001-07-25 | — | — | CN | disclosed |
| EP-1077947-A1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2001-02-28 | — | — | EP | disclosed |
| US-6166023-A | 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-12-26 | — | — | US | disclosed |
| WO-1999058503-A1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150320733-A1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | HSD11B1, CYP21A2, CYP11B1 | CYP11B2 4/4885CYP11B1 3/4885KDM4E 2494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.